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This episode of the podcast is going to explore psychedelic medicine as a treatment for chronic pain. our guest is Dr. Alex Bekker
Dr. Alex Bekker serves as Professor and Chairman of Anaesthesiology at Rutgers New Jersey Medical School. With doctoral degrees in both Biomedical Engineering (NJ Institute of Technology) and Medicine (Rutgers), he completed his anesthesia training at Columbia Presbyterian Medical Center before joining NYU Medical Center in 1995, where he later became Vice-Chair for Research. An internationally recognized expert in perioperative medicine, Dr. Bekker’s extensive research focuses on brain protection, neuropharmacology, and pain control. His credentials include 120 peer-reviewed publications in prestigious journals, 6 US patents, 40 educational reviews, and over 200 abstracts. He has led numerous clinical trials, including National Institute of Aging studies, serves on five journal editorial boards, and in 2017 was appointed Chair of the NJ Department of Health Medicinal Marijuana Review Panel.
He is also senior author on the paper “Psychedelics as novel therapeutic agents for chronic pain: mechanisms and future perspectives”
It is that paper he is on the show to talk about, specifically, he is on the show to talk to us about what chronic pain is, the different between chronic and acute pain, how chronic pain is related to what he refers to as maladaptive neuralplasticity, and how it is that psychedelics may be effective in treating chronic pain conditions that we presently have no completely effective drugs or therapies for.
As always, there are timestamps and/or chapters for this episode wherever you are checking it out (below), so feel free to look it over if there is a specific topic you want to jump right into.
Otherwise, enjoy!
Follow up links, suggested by Dr. Bekker
- UCSD Center for Psychedelic Research
- Center for Psychedelic & Consciousness Research (Hopkins)
- NYU Center for Psychedelic Medicine Research
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Episode Breakdown
- (5:00) The difference between acute pain (nociceptive) and chronic pain
- (8:24) Chronic pain as neuropathic sensitization (peripheral and central sensitization)
- (11:25) Chronic pain involved disrupted nociceptive neural-inhibitory pathways
- (12:36) Chronic pain and neural-inflammatory signals
- (14:44) Chronic pain as maladaptive neuroplasticity
- (16:56) DMN and chronic pain (maladaptive neuroplasticity)
- (19:57) Chronic pain is multifactorial (pain is biopsychosocial, not just biological)
- (23:02) Treatments of chronic pain (and why they don’t work)
- (34:45) Biological treatments are not enough
- (37:45) Social factors that reinforce chronic pain
- (40:09) Patreon Thanks
- (43:12) The mechanisms by which psychedelics may help with chronic pain
- (54:29) The role of psychotherapy in psychedelic for chronic pain
- (57:44) Psychedelics help us re-learn (and reopen critical learning periods)
- (1:06:31) Ketamine for the treatment of chronic pain
- (1:14:33) Psychedelic helping to correct our “addition” to pain through increasing our sense of connection
- (1:20:51) CLIP potential for psychedelic in chronic pain
- (1:23:44) Psychedelics for fibromyalgia
- (1:26:05) Psychedelic for cancer-related chronic pain
- (1:27:27) Psychedelics for Cluster headaches
- (1:27:32) CARD clusters
- (1:30:23) Psychedelic for phantom limb pain
- (1:31:16) What make James excited and hopeful with psychedelic medicine
- (1:34:00) Advice to those suffering for chronic pain (psychedelics and otherwise)
- (1:37:58) Follow-up info and socials for Dr. Bekker
- (1:39:39) Closing
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