Microdosing for Health, Healing, and Enhanced Performance | Jim Fadiman and Jordan Gruber ~ ATTMind 197

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A Guide to Microdosing: Benefits, Protocols & Safety

Psychedelic researchers James Fadiman and Jordan Gruber are the authors of the new book, Microdosing for Health, Healing, and Enhanced Performance (2025). They join us on Adventures Through The Mind to discuss microdosing protocols, benefits, current research, and safety considerations.

Promo image Jordan Gruber and James Fadiman, ATTMind Podcast James Jesso Throughout the interview, you will learn the practical basics of psychedelic microdosing—substances, dosage, frequency and duration, when in the larger arc of our lives, and who would best benefit from microdosing; You will also learn about the benefits of microdosing that Gruber and Faidman discovered in their research, which they describe as A-Z, anorexia to zoster and everything in between—with a particular focus later on in the interview on microdosing for various neurological and mental health conditions like ADHD, TBI, dementia, and depression—as well as for the betterment of well people

You’ll also learn some of the issues facing microdosing as a both a practice and a premise— issues like placebo, research design, and the potential dangers of microdosing.

Enjoy!

While Fadiman and Gruber provide comprehensive research on microdosing protocols, if you’re considering microdosing as part of your personal psychedelic practice and want individualized guidance on safety, intention-setting, and integration, my psychedelic integration coaching offers drug-positive support tailored to your specific needs.

Check out their book Microdosing for Health, Healing, and Enhanced Performance

or follow them on their new YouTube channel: @FadimanGruber

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Episode Breakdown

(00:00) Opening
(03:28) A quick request
(05:29) Interview begins
(07:13) What microdosing is, and what it is not
(08:33) the dose range for microdosing
(09:42) Bettering the terminology “Sub-threshold” rather than “sub-perceptual”
(15:00) The substances you can microdose (and those that don’t qualify and why)
(18:00) Fadiman and Gruber got their data from “real world evidence”
(20:57) The different microdosing protocols
(28:30) Why people tend to stop microdosing after a while
(30:54) Once isn’t enough with microdosing, and here’s why
(32:28) How consistent we need to be to see benefits
(37:53) How to time higher doses around microdoses, and vice versa
(40:26) What should “do” and “avoid” to help increase microdosing efficacy
(43:14) The value of parts work while microdosing
(45:54) The 4 things microdosing seems to do that contributes to its wide benefit profile
(49:11) How it is that microdosing seems to be helpful for nearly everything
(52:29) Is microdosing just placebo?
(1:01:45) The benefits of microdosing for already well people
(1:11:12) Patreon thanks and invitation
(1:14:24) Potential interactions between microdosing and the microbiome and the gut-brain axis
(1:20:48) The differences between LSD and Psilocybin microdosing
(1:26:02) Theory vs the real world
(1:32:24) How theories can compromise our ability to understand what is really happening
(1:37:12) San Pedro, ibogaine, and caapi microdosing
(1:45:41) Microdosing for ADHD (a new nighttime protocol)
(1:51:07) Microdosing for mTBI (concussion)
(1:57:41) Microdosing for dementia and palliative care
(2:03:52) Microdosing for fun (social microdosing)
(2:06:49) Microdosing makes the bad thing less bad, and the good things better
(2:08:43) Peri-threshold doses?
(2:12:09) The dangers/concerns for microdosing—heart valve damage, bipolar, tinnitus, anxiety, drug interaction, and tracers
(2:18:22) Follow-up links and socials
(2:20:36) Closing

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